Cargando…

Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo

Loss of function mutations in progranulin (GRN) cause frontotemporal dementia, but how GRN haploinsufficiency causes neuronal dysfunction remains unclear. We previously showed that GRN is neurotrophic in vitro. Here, we used an in vivo axonal outgrowth system and observed a delayed recovery in GRN(−...

Descripción completa

Detalles Bibliográficos
Autores principales:	Beel, Sander, Moisse, Matthieu, Damme, Markus, De Muynck, Louis, Robberecht, Wim, Van Den Bosch, Ludo, Saftig, Paul, Van Damme, Philip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886064/ https://www.ncbi.nlm.nih.gov/pubmed/28453791 http://dx.doi.org/10.1093/hmg/ddx162

Ejemplares similares

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice
por: Beel, Sander, et al.
Publicado: (2018)

Progranulin is Neurotrophic In Vivo and Protects against a Mutant TDP-43 Induced Axonopathy
por: Laird, Angela S., et al.
Publicado: (2010)

Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
por: Van Damme, Philip, et al.
Publicado: (2008)

Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot–Marie–Tooth Disease
por: Benoy, Veronick, et al.
Publicado: (2016)

Modelling amyotrophic lateral sclerosis: progress and possibilities
por: Van Damme, Philip, et al.
Publicado: (2017)

Histone Deacetylase Inhibition Regulates Lipid Homeostasis in a Mouse Model of Amyotrophic Lateral Sclerosis
por: Burg, Thibaut, et al.
Publicado: (2021)

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
por: Pollari, Eveliina, et al.
Publicado: (2018)

Restoration of Progranulin Expression Rescues Cortical Neuron Generation in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia
por: Raitano, Susanna, et al.
Publicado: (2014)

Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice
por: Herdewyn, Sarah, et al.
Publicado: (2014)

Conditional deletion of Id2 or Notch1 in oligodendrocyte progenitor cells does not ameliorate disease outcome in SOD1(G93A) mice
por: Eykens, Caroline, et al.
Publicado: (2018)

Another piece in the progranulin puzzle: special binding between progranulin and prosaposin creates additional lysosomal access: An Editorial Comment for ‘The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C’ on page 236
por: Van Damme, Philip
Publicado: (2017)

FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteins
por: Steyaert, Jolien, et al.
Publicado: (2018)

Tweaking Progranulin Expression: Therapeutic Avenues and Opportunities
por: Terryn, Joke, et al.
Publicado: (2021)

Beta-2 microglobulin is important for disease progression in a murine model for amyotrophic lateral sclerosis
por: Staats, Kim A., et al.
Publicado: (2013)

Restoration of histone acetylation ameliorates disease and metabolic abnormalities in a FUS mouse model
por: Rossaert, Elisabeth, et al.
Publicado: (2019)

Progranulin regulates neuronal outgrowth independent of Sortilin
por: Gass, Jennifer, et al.
Publicado: (2012)

RNA toxicity in non‐coding repeat expansion disorders
por: Swinnen, Bart, et al.
Publicado: (2019)

Rapamycin increases survival in ALS mice lacking mature lymphocytes
por: Staats, Kim A, et al.
Publicado: (2013)

Reducing EphA4 before disease onset does not affect survival in a mouse model of Amyotrophic Lateral Sclerosis
por: Rué, Laura, et al.
Publicado: (2019)

HDAC6 inhibition restores TDP‐43 pathology and axonal transport defects in human motor neurons with TARDBP mutations
por: Fazal, Raheem, et al.
Publicado: (2021)

The lysosomal protein cathepsin L is a progranulin protease
por: Lee, Chris W., et al.
Publicado: (2017)

Whole-genome sequencing reveals a coding non-pathogenic variant tagging a non-coding pathogenic hexanucleotide repeat expansion in C9orf72 as cause of amyotrophic lateral sclerosis
por: Herdewyn, Sarah, et al.
Publicado: (2012)

Inside out: the role of nucleocytoplasmic transport in ALS and FTLD
por: Boeynaems, Steven, et al.
Publicado: (2016)

Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy
por: Poppe, Lindsay, et al.
Publicado: (2019)

Commissureless Regulation of Axon Outgrowth across the Midline Is Independent of Rab Function
por: van den Brink, Daan M., et al.
Publicado: (2013)

MiR-145 mediates zebrafish hepatic outgrowth through progranulin A signaling
por: Li, Ya-Wen, et al.
Publicado: (2017)

HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients
por: Guo, Wenting, et al.
Publicado: (2017)

Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules
por: Vanneste, Joni, et al.
Publicado: (2022)

Progranulin acts as a shared chaperone and regulates multiple lysosomal enzymes
por: Jian, Jinlong, et al.
Publicado: (2017)

Microglia lacking a peroxisomal β-oxidation enzyme chronically alter their inflammatory profile without evoking neuronal and behavioral deficits
por: Beckers, Lien, et al.
Publicado: (2019)

Extracellular cathepsin L stimulates axonal growth in neurons
por: Tohda, Chihiro, et al.
Publicado: (2017)

Genetic ablation of IP(3) receptor 2 increases cytokines and decreases survival of SOD1(G93A) mice
por: Staats, Kim A., et al.
Publicado: (2016)

C9orf72-generated poly-GR and poly-PR do not directly interfere with nucleocytoplasmic transport
por: Vanneste, Joni, et al.
Publicado: (2019)

C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility
por: Fumagalli, Laura, et al.
Publicado: (2021)

HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease
por: Benoy, Veronick, et al.
Publicado: (2018)

Reduction of ephrin-A5 aggravates disease progression in amyotrophic lateral sclerosis
por: Rué, Laura, et al.
Publicado: (2019)

Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia
por: Telpoukhovskaia, Maria A., et al.
Publicado: (2020)

Loss of Progranulin Results in Increased Pan-Cathepsin Activity and Reduced LAMP1 Lysosomal Protein
por: Anderson, Abigail, et al.
Publicado: (2023)

Benefits of intensive insulin therapy on neuromuscular complications in routine daily critical care practice: a retrospective study
por: Hermans, Greet, et al.
Publicado: (2009)

EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer’s disease
por: Poppe, Lindsay, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_g95f3r8to1po4igeunnqarm2b0