Germline TP53 mutations result into a constitutive defect of p53 DNA binding and transcriptional response to DNA damage

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Li-Fraumeni Syndrome (LFS) results from heterozygous germline mutations of TP53, encoding a key transcriptional factor activated in response to DNA damage. We have recently shown, from a large LFS series, that dominant-negative missense mutations are the most clinically severe and, thanks to a new p...

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Detalles Bibliográficos
Autores principales: Zerdoumi, Yasmine, Lanos, Raphaël, Raad, Sabine, Flaman, Jean-Michel, Bougeard, Gaëlle, Frebourg, Thierry, Tournier, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886078/
https://www.ncbi.nlm.nih.gov/pubmed/28369373
http://dx.doi.org/10.1093/hmg/ddx106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886078/
https://www.ncbi.nlm.nih.gov/pubmed/28369373
http://dx.doi.org/10.1093/hmg/ddx106

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