Repeat-Associated Non-ATG (RAN) Translation in Fuchs' Endothelial Corneal Dystrophy

PURPOSE: The strongest genetic association with Fuchs' endothelial corneal dystrophy (FECD) is the presence of an intronic (CTG·CAG)(n) trinucleotide repeat (TNR) expansion in the transcription factor 4 (TCF4) gene. Repeat-associated non-ATG (RAN) translation, an unconventional protein translat...

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Detalles Bibliográficos
Autores principales: Soragni, Elisabetta, Petrosyan, Lina, Rinkoski, Tommy A., Wieben, Eric D., Baratz, Keith H., Fautsch, Michael P., Gottesfeld, Joel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2018
Materias:
Cornea
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886103/
https://www.ncbi.nlm.nih.gov/pubmed/29677349
http://dx.doi.org/10.1167/iovs.17-23265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886103/
https://www.ncbi.nlm.nih.gov/pubmed/29677349
http://dx.doi.org/10.1167/iovs.17-23265

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