Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome

Mitochondrial disorders affecting oxidative phosphorylation (OxPhos) are caused by mutations in both the nuclear and mitochondrial genomes. One promising candidate for treatment is the drug rapamycin, which has been shown to extend lifespan in multiple animal models, and which was previously shown t...

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Detalles Bibliográficos
Autores principales: Siegmund, Stephanie E, Yang, Hua, Sharma, Rohit, Javors, Martin, Skinner, Owen, Mootha, Vamsi, Hirano, Michio, Schon, Eric A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886265/
https://www.ncbi.nlm.nih.gov/pubmed/28973153
http://dx.doi.org/10.1093/hmg/ddx341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886265/
https://www.ncbi.nlm.nih.gov/pubmed/28973153
http://dx.doi.org/10.1093/hmg/ddx341

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