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Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal

It is clear that innate immune system status is altered in numerous neurodegenerative diseases. Human genetic studies have demonstrated that triggering receptor expressed in myeloid cells 2 (TREM2) coding variants have a strong association with Alzheimer’s disease (AD) and other neurodegenerative di...

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Detalles Bibliográficos
Autores principales: Kang, Silvia S, Kurti, Aishe, Baker, Kelsey E, Liu, Chia-Chen, Colonna, Marco, Ulrich, Jason D, Holtzman, David M, Bu, Guojun, Fryer, John D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886290/
https://www.ncbi.nlm.nih.gov/pubmed/29040522
http://dx.doi.org/10.1093/hmg/ddx366