Structural insights into the voltage and phospholipid activation of mammalian TPC1 channel

Organellar two-pore channels (TPCs) function as a homodimer with each subunit containing two homologous Shaker-like 6-TM repeats(1). They belong to the voltage-gated ion channel superfamily(2) and are ubiquitously expressed in animals and plants(3,4). Mammalian TPC1 and TPC2 are localized to the end...

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Detalles Bibliográficos
Autores principales: She, Ji, Guo, Jiangtao, Chen, Qingfeng, Zeng, Weizhong, Jiang, Youxing, Bai, Xiao-chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886804/
https://www.ncbi.nlm.nih.gov/pubmed/29562233
http://dx.doi.org/10.1038/nature26139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886804/
https://www.ncbi.nlm.nih.gov/pubmed/29562233
http://dx.doi.org/10.1038/nature26139

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