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Structural insights into the voltage and phospholipid activation of mammalian TPC1 channel

Organellar two-pore channels (TPCs) function as a homodimer with each subunit containing two homologous Shaker-like 6-TM repeats(1). They belong to the voltage-gated ion channel superfamily(2) and are ubiquitously expressed in animals and plants(3,4). Mammalian TPC1 and TPC2 are localized to the end...

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Detalles Bibliográficos
Autores principales:	She, Ji, Guo, Jiangtao, Chen, Qingfeng, Zeng, Weizhong, Jiang, Youxing, Bai, Xiao-chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886804/ https://www.ncbi.nlm.nih.gov/pubmed/29562233 http://dx.doi.org/10.1038/nature26139

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