SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of cMYC oncoprotein

The E3 ubiquitin ligase adaptor speckle-type POZ protein (SPOP) is frequently dysregulated in prostate adenocarcinoma (PC), via either somatic mutations or mRNA downregulation, suggesting an important tumor suppressor function. To examine its physiologic role in the prostate epithelium in vivo, we g...

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Detalles Bibliográficos
Autores principales: Geng, Chuandong, Kaochar, Salma, Li, Min, Rajapakshe, Kimal, Fiskus, Warren, Dong, Jianrong, Foley, Christopher, Dong, Boming, Zhang, Li, Kwon, Oh-Joon, Shah, Shrijal S., Bolaki, Menaka, Xin, Li, Ittmann, Michael, O’Malley, Bert W., Coarfa, Cristian, Mitsiades, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887163/
https://www.ncbi.nlm.nih.gov/pubmed/28414305
http://dx.doi.org/10.1038/onc.2017.80

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887163/
https://www.ncbi.nlm.nih.gov/pubmed/28414305
http://dx.doi.org/10.1038/onc.2017.80

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