A factor XIa-activatable hirudin-albumin fusion protein reduces thrombosis in mice without promoting blood loss

BACKGROUND: Hirudin is a potent thrombin inhibitor but its antithrombotic properties are offset by bleeding side-effects. Because hirudin’s N-terminus must engage thrombin’s active site for effective inhibition, fusing a cleavable peptide at this site may improve hirudin’s risk/benefit ratio as a th...

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Detalles Bibliográficos
Autores principales: Sheffield, William P., Eltringham-Smith, Louise J., Bhakta, Varsha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887181/
https://www.ncbi.nlm.nih.gov/pubmed/29621998
http://dx.doi.org/10.1186/s12896-018-0431-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887181/
https://www.ncbi.nlm.nih.gov/pubmed/29621998
http://dx.doi.org/10.1186/s12896-018-0431-4

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