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A factor XIa-activatable hirudin-albumin fusion protein reduces thrombosis in mice without promoting blood loss
BACKGROUND: Hirudin is a potent thrombin inhibitor but its antithrombotic properties are offset by bleeding side-effects. Because hirudin’s N-terminus must engage thrombin’s active site for effective inhibition, fusing a cleavable peptide at this site may improve hirudin’s risk/benefit ratio as a th...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887181/ https://www.ncbi.nlm.nih.gov/pubmed/29621998 http://dx.doi.org/10.1186/s12896-018-0431-4 |