Mitochonic acid 5 activates the MAPK–ERK–yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy

BACKGROUND: The regulation of microglial function via mitochondrial homeostasis is important in the development of neuroinflammation. The underlying mechanism for this regulatory function remains unclear. In this study, we investigated the protective role of mitochonic acid 5 (MA-5) in microglial mi...

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Detalles Bibliográficos
Autores principales: Lei, Qingyun, Tan, Jian, Yi, Shangqing, Wu, Na, Wang, Yilin, Wu, Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887257/
https://www.ncbi.nlm.nih.gov/pubmed/29636771
http://dx.doi.org/10.1186/s11658-018-0081-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887257/
https://www.ncbi.nlm.nih.gov/pubmed/29636771
http://dx.doi.org/10.1186/s11658-018-0081-5

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