Engineering CRISPR interference system in Klebsiella pneumoniae for attenuating lactic acid synthesis

BACKGROUND: Klebsiella pneumoniae is a promising industrial species for bioproduction of bulk chemicals such as 1,3-propanediol, 2,3-butanediol and 3-hydroxypropionic acid (3-HP). However, lactic acid is a troublesome by-product when optimizing for 3-HP production. Therefore, it is highly desirable...

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Detalles Bibliográficos
Autores principales: Wang, Jingxuan, Zhao, Peng, Li, Ying, Xu, Lida, Tian, Pingfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887262/
https://www.ncbi.nlm.nih.gov/pubmed/29622042
http://dx.doi.org/10.1186/s12934-018-0903-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887262/
https://www.ncbi.nlm.nih.gov/pubmed/29622042
http://dx.doi.org/10.1186/s12934-018-0903-1

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