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Engineering CRISPR interference system in Klebsiella pneumoniae for attenuating lactic acid synthesis

BACKGROUND: Klebsiella pneumoniae is a promising industrial species for bioproduction of bulk chemicals such as 1,3-propanediol, 2,3-butanediol and 3-hydroxypropionic acid (3-HP). However, lactic acid is a troublesome by-product when optimizing for 3-HP production. Therefore, it is highly desirable...

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Detalles Bibliográficos
Autores principales:	Wang, Jingxuan, Zhao, Peng, Li, Ying, Xu, Lida, Tian, Pingfang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887262/ https://www.ncbi.nlm.nih.gov/pubmed/29622042 http://dx.doi.org/10.1186/s12934-018-0903-1

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