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Translational profiling of B cells infected with the Epstein-Barr virus reveals 5′ leader ribosome recruitment through upstream open reading frames

The Epstein-Barr virus (EBV) genome encodes several hundred transcripts. We have used ribosome profiling to characterize viral translation in infected cells and map new translation initiation sites. We show here that EBV transcripts are translated with highly variable efficiency, owing to variable t...

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Detalles Bibliográficos
Autores principales: Bencun, Maja, Klinke, Olaf, Hotz-Wagenblatt, Agnes, Klaus, Severina, Tsai, Ming-Han, Poirey, Remy, Delecluse, Henri-Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887285/
https://www.ncbi.nlm.nih.gov/pubmed/29529302
http://dx.doi.org/10.1093/nar/gky129