The DNMT3A R882H mutant displays altered flanking sequence preferences

The DNMT3A R882H mutation is frequently observed in acute myeloid leukemia (AML). It is located in the subunit and DNA binding interface of DNMT3A and has been reported to cause a reduction in activity and dominant negative effects. We investigated the mechanistic consequences of the R882H mutation...

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Detalles Bibliográficos
Autores principales: Emperle, Max, Rajavelu, Arumugam, Kunert, Stefan, Arimondo, Paola B, Reinhardt, Richard, Jurkowska, Renata Z, Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887309/
https://www.ncbi.nlm.nih.gov/pubmed/29518238
http://dx.doi.org/10.1093/nar/gky168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887309/
https://www.ncbi.nlm.nih.gov/pubmed/29518238
http://dx.doi.org/10.1093/nar/gky168

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