Combined roles of ATP and small hairpin RNA in the activation of RIG-I revealed by solution-based analysis

RIG-I (retinoic acid inducible gene-I) is a cytosolic innate immune protein that senses viral dsRNA with a 5′-triphosphate overhang. Upon interaction with dsRNA a de-repression of the RIG-I CARD domains takes place that ultimately leads to the production of type I interferons and pro-inflammatory cy...

Descripción completa

Detalles Bibliográficos
Autores principales: Shah, Neelam, Beckham, Simone A, Wilce, Jacqueline A, Wilce, Matthew C J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887321/
https://www.ncbi.nlm.nih.gov/pubmed/29346611
http://dx.doi.org/10.1093/nar/gkx1307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887321/
https://www.ncbi.nlm.nih.gov/pubmed/29346611
http://dx.doi.org/10.1093/nar/gkx1307

Ejemplares similares