Cargando…

Direct observation of nucleic acid binding dynamics by the telomerase essential N-terminal domain

Telomerase is a specialized enzyme that maintains telomere length by adding DNA repeats to chromosome ends. The catalytic protein subunit of telomerase utilizes the integral telomerase RNA to direct telomere DNA synthesis. The telomerase essential N-terminal (TEN) domain is required for enzyme funct...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shastry, Shankar, Steinberg-Neifach, Olga, Lue, Neal, Stone, Michael D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887506/ https://www.ncbi.nlm.nih.gov/pubmed/29474579 http://dx.doi.org/10.1093/nar/gky117

Ejemplares similares

The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA–DNA hybrids
por: Akiyama, Benjamin M., et al.
Publicado: (2015)

Direct involvement of the TEN domain at the active site of human telomerase
por: Jurczyluk, Julie, et al.
Publicado: (2011)

Multiple DNA-binding sites in Tetrahymena telomerase
por: Finger, Sharon N., et al.
Publicado: (2008)

The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization
por: Sealey, David C. F., et al.
Publicado: (2010)

The domain structure of Helicobacter pylori DnaB helicase: the N-terminal domain can be dispensable for helicase activity whereas the extreme C-terminal region is essential for its function
por: Nitharwal, Ram Gopal, et al.
Publicado: (2007)

DNA binding and synapsis by the large C-terminal domain of ϕC31 integrase
por: McEwan, Andrew R., et al.
Publicado: (2009)

The Rrp6 C-terminal domain binds RNA and activates the nuclear RNA exosome
por: Wasmuth, Elizabeth V., et al.
Publicado: (2017)

The N-terminal domain of TWINKLE contributes to single-stranded DNA binding and DNA helicase activities
por: Farge, Géraldine, et al.
Publicado: (2008)

A motif in the C-terminal domain of ϕC31 integrase controls the directionality of recombination
por: Rowley, Paul A., et al.
Publicado: (2008)

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase
por: Redon, Sophie, et al.
Publicado: (2010)

Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p
por: Zappulla, David C., et al.
Publicado: (2009)

Carboxyl terminal domain basic amino acids of mycobacterial topoisomerase I bind DNA to promote strand passage
por: Ahmed, Wareed, et al.
Publicado: (2013)

Human H4 tail stimulates HIV-1 integration through binding to the carboxy-terminal domain of integrase
por: Mauro, Eric, et al.
Publicado: (2019)

The DEAH-box RNA helicase Dhr1 contains a remarkable carboxyl terminal domain essential for small ribosomal subunit biogenesis
por: Roychowdhury, Amlan, et al.
Publicado: (2019)

The key DNA-binding residues in the C-terminal domain of Mycobacterium tuberculosis DNA gyrase A subunit (GyrA)
por: Huang, You-Yi, et al.
Publicado: (2006)

Archaeal DnaG contains a conserved N-terminal RNA-binding domain and enables tailing of rRNA by the exosome
por: Hou, Linlin, et al.
Publicado: (2014)

Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics
por: Orris, Benjamin, et al.
Publicado: (2022)

Modulation of telomere terminal structure by telomerase components in Candida albicans
por: Steinberg-Neifach, Olga, et al.
Publicado: (2006)

Polymerization and nucleic acid-binding properties of human L1 ORF1 protein
por: Callahan, Kathryn E., et al.
Publicado: (2012)

Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity
por: Syed, Aleem, et al.
Publicado: (2023)

A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain
por: Carayon, Kevin, et al.
Publicado: (2010)

Terminal deoxynucleotidyl transferase-mediated formation of protein binding polynucleotides
por: Ashley, Jon, et al.
Publicado: (2021)

The solution structure of the amino-terminal domain of human DNA polymerase ε subunit B is homologous to C-domains of AAA+ proteins
por: Nuutinen, Tarmo, et al.
Publicado: (2008)

Biochemical analysis of human PIF1 helicase and functions of its N-terminal domain
por: Gu, Yongqing, et al.
Publicado: (2008)

Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays
por: Mukherjee, Sourav, et al.
Publicado: (2012)

SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity
por: Seamon, Kyle J., et al.
Publicado: (2015)

C-terminal domain of archaeal O-phosphoseryl-tRNA kinase displays large-scale motion to bind the 7-bp D-stem of archaeal tRNA(Sec)
por: Sherrer, R. Lynn, et al.
Publicado: (2011)

Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains
por: Fiorini, Francesca, et al.
Publicado: (2013)

A three-state model for the regulation of telomerase by TERRA and hnRNPA1
por: Redon, Sophie, et al.
Publicado: (2013)

Crystal structure of the Redβ C-terminal domain in complex with λ Exonuclease reveals an unexpected homology with λ Orf and an interaction with Escherichia coli single stranded DNA binding protein
por: Caldwell, Brian J, et al.
Publicado: (2019)

The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase
por: Vijayakumar, Sangeetha, et al.
Publicado: (2007)

DNA chirality-dependent stimulation of topoisomerase IV activity by the C-terminal AAA+ domain of FtsK
por: Bigot, Sarah, et al.
Publicado: (2010)

Crucial role of the C-terminal domain of Mycobacterium tuberculosis leucyl-tRNA synthetase in aminoacylation and editing
por: Hu, Qing-Hua, et al.
Publicado: (2013)

Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage
por: Datta, Kausiki, et al.
Publicado: (2013)

Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint
por: Kozuki, Toshiyuki, et al.
Publicado: (2017)

Involvement of SRSF11 in cell cycle-specific recruitment of telomerase to telomeres at nuclear speckles
por: Lee, Ji Hoon, et al.
Publicado: (2015)

Point mutations in the Rpb9-homologous domain of Rpc11 that impair transcription termination by RNA polymerase III
por: Iben, James R., et al.
Publicado: (2011)

Drosophila melanogaster Dis3 N-terminal domains are required for ribonuclease activities, nuclear localization and exosome interactions
por: Mamolen, Megan, et al.
Publicado: (2010)

Brr2p carboxy-terminal Sec63 domain modulates Prp16 splicing RNA helicase
por: Cordin, Olivier, et al.
Publicado: (2014)

Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT
por: Xi, Linghe, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_g2mtjb9ajadksbpuslm99mi7dj