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Total chemical synthesis of ester-linked ubiquitinated proteins unravels their behavior with deubiquitinases

Ester-linked ubiquitinated proteins have been reported by several groups to be involved in ubiquitin signalling. However, due to the lack of the suitable tools to homogeneously produce such conjugates, their exact physiological roles and biochemical behavior remain enigmatic. Here, we report for the...

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Detalles Bibliográficos
Autores principales: Sun, Hao, Meledin, Roman, Mali, Sachitanand M., Brik, Ashraf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887810/
https://www.ncbi.nlm.nih.gov/pubmed/29675213
http://dx.doi.org/10.1039/c7sc04518b