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Role of 5-HT(1A) Receptor Stimulation in the Medial Prefrontal Cortex in the Sustained Antidepressant Effects of Ketamine

BACKGROUND: We previously reported that serotonergic transmission plays an important role in antidepressant effects of ketamine. However, detailed mechanisms have not been elucidated. Among the serotonin receptor subtypes, the serotonin(1A) receptor in the medial prefrontal cortex has an important r...

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Detalles Bibliográficos
Autores principales: Fukumoto, Kenichi, Iijima, Michihiko, Funakoshi, Takeo, Chaki, Shigeyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888010/
https://www.ncbi.nlm.nih.gov/pubmed/29309585
http://dx.doi.org/10.1093/ijnp/pyx116