Structurally distinct Mre11 domains mediate MRX functions in resection, end-tethering and DNA damage resistance

Sae2 cooperates with the Mre11–Rad50-Xrs2 (MRX) complex to initiate resection of DNA double-strand breaks (DSBs) and to maintain the DSB ends in close proximity to allow their repair. How these diverse MRX-Sae2 functions contribute to DNA damage resistance is not known. Here, we describe mre11 allel...

Descripción completa

Detalles Bibliográficos
Autores principales: Cassani, Corinne, Gobbini, Elisa, Vertemara, Jacopo, Wang, Weibin, Marsella, Antonio, Sung, Patrick, Tisi, Renata, Zampella, Giuseppe, Longhese, Maria Pia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888019/
https://www.ncbi.nlm.nih.gov/pubmed/29420790
http://dx.doi.org/10.1093/nar/gky086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888019/
https://www.ncbi.nlm.nih.gov/pubmed/29420790
http://dx.doi.org/10.1093/nar/gky086

Ejemplares similares