F196. DIFFERENTIAL EFFECTS OF MGLU5 RECEPTOR BLOCKADE ON BEHAVIOR, SCHIZOPHRENIA-RELEVANT GENE EXPRESSION AND NEURONAL ACTIVATION PATTERNS FROM DEVELOPMENT TO AGING MICE

BACKGROUND: The glutamate system is implicated both in schizophrenia and mood disorders. Mice lacking metabotropic mGlu5 receptors (mGluR5 KO) display schizophrenia-like abnormalities. Additionally, mGluR5 antagonists represent promising alternative anxiolytics/antidepressants. However, the underlyi...

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Detalles Bibliográficos
Autores principales: Inta, Dragos, Luoni, Alessia, Riva, Marco A, Gass, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888163/
http://dx.doi.org/10.1093/schbul/sby017.727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888163/
http://dx.doi.org/10.1093/schbul/sby017.727

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