Missed cleavage opportunities by FEN1 lead to Okazaki fragment maturation via the long-flap pathway

RNA–DNA hybrid primers synthesized by low fidelity DNA polymerase α to initiate eukaryotic lagging strand synthesis must be removed efficiently during Okazaki fragment (OF) maturation to complete DNA replication. In this process, each OF primer is displaced and the resulting 5′-single-stranded flap...

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Detalles Bibliográficos
Autores principales: Zaher, Manal S, Rashid, Fahad, Song, Bo, Joudeh, Luay I, Sobhy, Mohamed A, Tehseen, Muhammad, Hingorani, Manju M, Hamdan, Samir M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888579/
https://www.ncbi.nlm.nih.gov/pubmed/29420814
http://dx.doi.org/10.1093/nar/gky082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888579/
https://www.ncbi.nlm.nih.gov/pubmed/29420814
http://dx.doi.org/10.1093/nar/gky082

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