Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination

In order to expand the current repertoire of cancer treatments and to help circumvent limitations associated with resistance, the identification of new metallodrugs with high potency and novel mechanisms of action is of significant importance. Here we present a class of di-copper(II) complex based o...

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Detalles Bibliográficos
Autores principales: Slator, Creina, Molphy, Zara, McKee, Vickie, Long, Conor, Brown, Tom, Kellett, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888725/
https://www.ncbi.nlm.nih.gov/pubmed/29474633
http://dx.doi.org/10.1093/nar/gky105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888725/
https://www.ncbi.nlm.nih.gov/pubmed/29474633
http://dx.doi.org/10.1093/nar/gky105

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