Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen

The specificity of tyrosine kinases is attributed predominantly to localization effects dictated by non-catalytic domains. We developed a method to profile the specificities of tyrosine kinases by combining bacterial surface-display of peptide libraries with next-generation sequencing. Using this, w...

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Detalles Bibliográficos
Autores principales: Shah, Neel H, Löbel, Mark, Weiss, Arthur, Kuriyan, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889215/
https://www.ncbi.nlm.nih.gov/pubmed/29547119
http://dx.doi.org/10.7554/eLife.35190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889215/
https://www.ncbi.nlm.nih.gov/pubmed/29547119
http://dx.doi.org/10.7554/eLife.35190

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