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Ribothrypsis, a novel process of canonical mRNA decay, mediates ribosome-phased mRNA endonucleolysis

Messenger RNAs transmit the genetic information that dictates protein production, and are a nexus for numerous pathways that regulate gene expression. The prevailing view of canonical mRNA decay is that it is mediated by deadenylation and decapping followed by exonucleolysis from the 3′ and 5′ ends....

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Detalles Bibliográficos
Autores principales: Ibrahim, Fadia, Maragkakis, Manolis, Alexiou, Panagiotis, Mourelatos, Zissimos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889319/
https://www.ncbi.nlm.nih.gov/pubmed/29507394
http://dx.doi.org/10.1038/s41594-018-0042-8