A novel interaction between CX(3)CR(1) and CCR(2) signalling in monocytes constitutes an underlying mechanism for persistent vincristine-induced pain

BACKGROUND: A dose-limiting side effect of chemotherapeutic agents such as vincristine (VCR) is neuropathic pain, which is poorly managed at present. Chemokine-mediated immune cell/neuron communication in preclinical VCR-induced pain forms an intriguing basis for the development of analgesics. In a...

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Detalles Bibliográficos
Autores principales: Montague, Karli, Simeoli, Raffaele, Valente, Joao, Malcangio, Marzia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889528/
https://www.ncbi.nlm.nih.gov/pubmed/29625610
http://dx.doi.org/10.1186/s12974-018-1116-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889528/
https://www.ncbi.nlm.nih.gov/pubmed/29625610
http://dx.doi.org/10.1186/s12974-018-1116-6

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