PDGFRα(+) pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo

Wnts and R-spondins (RSPOs) support intestinal homeostasis by regulating crypt cell proliferation and differentiation. Ex vivo, Wnts secreted by Paneth cells in organoids can regulate the proliferation and differentiation of Lgr5-expressing intestinal stem cells. However, in vivo, Paneth cell and in...

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Detalles Bibliográficos
Autores principales: Greicius, Gediminas, Kabiri, Zahra, Sigmundsson, Kristmundur, Liang, Chao, Bunte, Ralph, Singh, Manvendra K., Virshup, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889626/
https://www.ncbi.nlm.nih.gov/pubmed/29559533
http://dx.doi.org/10.1073/pnas.1713510115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889626/
https://www.ncbi.nlm.nih.gov/pubmed/29559533
http://dx.doi.org/10.1073/pnas.1713510115

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