Ligand channel in pharmacologically stabilized rhodopsin

In the degenerative eye disease retinitis pigmentosa (RP), protein misfolding leads to fatal consequences for cell metabolism and rod and cone cell survival. To stop disease progression, a therapeutic approach focuses on stabilizing inherited protein mutants of the G protein-coupled receptor (GPCR)...

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Detalles Bibliográficos
Autores principales: Mattle, Daniel, Kuhn, Bernd, Aebi, Johannes, Bedoucha, Marc, Kekilli, Demet, Grozinger, Nathalie, Alker, Andre, Rudolph, Markus G., Schmid, Georg, Schertler, Gebhard F. X., Hennig, Michael, Standfuss, Jörg, Dawson, Roger J. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889642/
https://www.ncbi.nlm.nih.gov/pubmed/29555765
http://dx.doi.org/10.1073/pnas.1718084115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889642/
https://www.ncbi.nlm.nih.gov/pubmed/29555765
http://dx.doi.org/10.1073/pnas.1718084115

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