Diversification of AID/APOBEC-like deaminases in metazoa: multiplicity of clades and widespread roles in immunity

AID/APOBEC deaminases (AADs) convert cytidine to uridine in single-stranded nucleic acids. They are involved in numerous mutagenic processes, including those underpinning vertebrate innate and adaptive immunity. Using a multipronged sequence analysis strategy, we uncover several AADs across metazoa,...

Descripción completa

Detalles Bibliográficos
Autores principales: Krishnan, Arunkumar, Iyer, Lakshminarayan M., Holland, Stephen J., Boehm, Thomas, Aravind, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889660/
https://www.ncbi.nlm.nih.gov/pubmed/29555751
http://dx.doi.org/10.1073/pnas.1720897115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889660/
https://www.ncbi.nlm.nih.gov/pubmed/29555751
http://dx.doi.org/10.1073/pnas.1720897115

Ejemplares similares