Ex Vivo Cardiotoxicity of Antineoplastic Casiopeinas Is Mediated through Energetic Dysfunction and Triggered Mitochondrial-Dependent Apoptosis

Casiopeinas are a group of copper-based antineoplastic molecules designed as a less toxic and more therapeutic alternative to cisplatin or Doxorubicin; however, there is scarce evidence about their toxic effects on the whole heart and cardiomyocytes. Given this, rat hearts were perfused with Casiope...

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Detalles Bibliográficos
Autores principales: Silva-Platas, Christian, Villegas, César A., Oropeza-Almazán, Yuriana, Carrancá, Mariana, Torres-Quintanilla, Alejandro, Lozano, Omar, Valero-Elizondo, Javier, Castillo, Elena C., Bernal-Ramírez, Judith, Fernández-Sada, Evaristo, Vega, Luis F., Treviño-Saldaña, Niria, Chapoy-Villanueva, Héctor, Ruiz-Azuara, Lena, Hernández-Brenes, Carmen, Elizondo-Montemayor, Leticia, Guerrero-Beltrán, Carlos E., Carvajal, Karla, Bravo-Gómez, María E., García-Rivas, Gerardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889877/
https://www.ncbi.nlm.nih.gov/pubmed/29765507
http://dx.doi.org/10.1155/2018/8949450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889877/
https://www.ncbi.nlm.nih.gov/pubmed/29765507
http://dx.doi.org/10.1155/2018/8949450

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