RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation

Aicardi–Goutières syndrome (AGS) is a rare early onset childhood encephalopathy caused by persistent neuroinflammation of autoimmune origin. AGS is a genetic disorder and >50% of affected individuals bear hypomorphic mutations in ribonuclease H2 (RNase H2). All available RNase H2 mouse models so...

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Detalles Bibliográficos
Autores principales: Bartsch, Kareen, Damme, Markus, Regen, Tommy, Becker, Lore, Garrett, Lillian, Hölter, Sabine M, Knittler, Katharina, Borowski, Christopher, Waisman, Ari, Glatzel, Markus, Fuchs, Helmut, Gailus-Durner, Valerie, Hrabe de Angelis, Martin, Rabe, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890188/
https://www.ncbi.nlm.nih.gov/pubmed/29662492
http://dx.doi.org/10.3389/fimmu.2018.00587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890188/
https://www.ncbi.nlm.nih.gov/pubmed/29662492
http://dx.doi.org/10.3389/fimmu.2018.00587

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