Synthesis and substrate properties towards HIV-1 reverse transcriptase of new diphosphate analogues of 9-[(2-phosphonomethoxy)ethyl]adenine

BACKGROUND: The replacement of β,γ-pyrophosphate by β,γ-phosphonate moieties within the triphosphate chain of 5′-triphosphate nucleoside analogues was previously studied for various antiviral nucleoside analogues such as AZT and 2′,3′-dideoxynucleosides. Thus, it has been shown that these chemical m...

Descripción completa

Detalles Bibliográficos
Autores principales: Laux, Wolfgang HG, Priet, Stéphane, Alvarez, Karine, Peyrottes, Suzanne, Périgaud, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890543/
https://www.ncbi.nlm.nih.gov/pubmed/29436843
http://dx.doi.org/10.1177/2040206618757636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890543/
https://www.ncbi.nlm.nih.gov/pubmed/29436843
http://dx.doi.org/10.1177/2040206618757636

Ejemplares similares