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Uromodulin rs4293393 T>C variation is associated with kidney disease in patients with type 2 diabetes

BACKGROUND & OBJECTIVES: Uromodulin, a UMOD gene encoded glycoprotein is synthesized exclusively in renal tubular cells and released into urine. Mutations lead to uromodulin misfolding and retention in the kidney, where it might stimulate cells of immune system to cause inflammation and progress...

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Detalles Bibliográficos
Autores principales: Kumar, Vinod, Yadav, Ashok Kumar, Kumar, Vivek, Bhansali, Anil, Jha, Vivekanand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890591/
https://www.ncbi.nlm.nih.gov/pubmed/29578190
http://dx.doi.org/10.4103/ijmr.IJMR_919_16