CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells

OBJECTIVE: Cancer stem cells (CSCs) are responsible for tumour formation and spreading, and their targeting is required for tumour eradication. There are limited therapeutic options for advanced colorectal cancer (CRC), particularly for tumours carrying RAS-activating mutations. The aim of this stud...

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Detalhes bibliográficos
Principais autores: Manic, Gwenola, Signore, Michele, Sistigu, Antonella, Russo, Giorgio, Corradi, Francesca, Siteni, Silvia, Musella, Martina, Vitale, Sara, De Angelis, Maria Laura, Pallocca, Matteo, Amoreo, Carla Azzurra, Sperati, Francesca, Di Franco, Simone, Barresi, Sabina, Policicchio, Eleonora, De Luca, Gabriele, De Nicola, Francesca, Mottolese, Marcella, Zeuner, Ann, Fanciulli, Maurizio, Stassi, Giorgio, Maugeri-Saccà, Marcello, Baiocchi, Marta, Tartaglia, Marco, Vitale, Ilio, De Maria, Ruggero
Formato: Online Atigo Texto
Idioma:English
Publicado em: BMJ Publishing Group 2018
Assuntos:
Colon
Acesso em linha:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890648/
https://www.ncbi.nlm.nih.gov/pubmed/28389531
http://dx.doi.org/10.1136/gutjnl-2016-312623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890648/
https://www.ncbi.nlm.nih.gov/pubmed/28389531
http://dx.doi.org/10.1136/gutjnl-2016-312623

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