SAR study on N(2),N(4)-disubstituted pyrimidine-2,4-diamines as effective CDK2/CDK9 inhibitors and antiproliferative agents

Cyclin-dependent kinases (CDKs) are pivotal kinases in cell cycle transition and gene transcription. A series of N(2),N(4)-diphenylpyrimidine-2,4-diamines were previously identified as potent CDK2/CDK9 inhibitors. To explore the SAR of this structural prototype, twenty-four novel N(2),N(4)-disubstit...

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Detalles Bibliográficos
Autores principales: Jing, Liandong, Tang, Yanbo, Goto, Masuo, Lee, Kuo-Hsiung, Xiao, Zhiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890689/
https://www.ncbi.nlm.nih.gov/pubmed/29682280
http://dx.doi.org/10.1039/c8ra01440j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890689/
https://www.ncbi.nlm.nih.gov/pubmed/29682280
http://dx.doi.org/10.1039/c8ra01440j

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