A densely modified M(2+)-independent DNAzyme that cleaves RNA efficiently with multiple catalytic turnover

Sequence-specific cleavage of RNA targets in the absence of a divalent metal cation (M(2+)) has been a long-standing goal in bioorganic chemistry. Herein, we report the in vitro selection of novel RNA cleaving DNAzymes that are selected using 8-histaminyl-deoxyadenosine (dA(im)TP), 5-guanidinoallyl-...

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Detalles Bibliográficos
Autores principales: Wang, Yajun, Liu, Erkai, Lam, Curtis H., Perrin, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890787/
https://www.ncbi.nlm.nih.gov/pubmed/29675226
http://dx.doi.org/10.1039/c7sc04491g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890787/
https://www.ncbi.nlm.nih.gov/pubmed/29675226
http://dx.doi.org/10.1039/c7sc04491g

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