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A densely modified M(2+)-independent DNAzyme that cleaves RNA efficiently with multiple catalytic turnover
Sequence-specific cleavage of RNA targets in the absence of a divalent metal cation (M(2+)) has been a long-standing goal in bioorganic chemistry. Herein, we report the in vitro selection of novel RNA cleaving DNAzymes that are selected using 8-histaminyl-deoxyadenosine (dA(im)TP), 5-guanidinoallyl-...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890787/ https://www.ncbi.nlm.nih.gov/pubmed/29675226 http://dx.doi.org/10.1039/c7sc04491g |