XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent

We have reported that the radical scavenger XJB-5-131 attenuates or reverses progression of the disease phenotype in the HdhQ(150/150) mouse, a slow onset model of HD. Here, we tested whether XJB-5-131 has beneficial effects in R6/2 mice, a severe early onset model of HD. We found that XJB-5-131 has...

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Detalles Bibliográficos
Autores principales: Polyzos, Aris A., Wood, Nigel I., Williams, Paul, Wipf, Peter, Morton, A. Jennifer, McMurray, Cynthia T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890981/
https://www.ncbi.nlm.nih.gov/pubmed/29630611
http://dx.doi.org/10.1371/journal.pone.0194580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890981/
https://www.ncbi.nlm.nih.gov/pubmed/29630611
http://dx.doi.org/10.1371/journal.pone.0194580

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