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XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent
We have reported that the radical scavenger XJB-5-131 attenuates or reverses progression of the disease phenotype in the HdhQ(150/150) mouse, a slow onset model of HD. Here, we tested whether XJB-5-131 has beneficial effects in R6/2 mice, a severe early onset model of HD. We found that XJB-5-131 has...
Autores principales: | Polyzos, Aris A., Wood, Nigel I., Williams, Paul, Wipf, Peter, Morton, A. Jennifer, McMurray, Cynthia T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890981/ https://www.ncbi.nlm.nih.gov/pubmed/29630611 http://dx.doi.org/10.1371/journal.pone.0194580 |
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