Thiopurine methyltransferase genotype and activity cannot predict outcomes of azathioprine maintenance therapy for antineutrophil cytoplasmic antibody associated vasculitis: A retrospective cohort study

OBJECTIVE: Azathioprine is a widely used immunosuppressive drug. Genetic polymorphisms and activity of the enzyme thiopurine methyltransferase (TPMT) have been associated with azathioprine efficacy and toxicity in several populations. We investigated whether these associations also exist for ANCA as...

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Detalles Bibliográficos
Autores principales: Hessels, Arno C., Rutgers, Abraham, Sanders, Jan Stephan F., Stegeman, Coen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890988/
https://www.ncbi.nlm.nih.gov/pubmed/29630648
http://dx.doi.org/10.1371/journal.pone.0195524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890988/
https://www.ncbi.nlm.nih.gov/pubmed/29630648
http://dx.doi.org/10.1371/journal.pone.0195524

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