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An antibody with Fab-constant domains exchanged for a pair of C(H)3 domains
We have designed a complete antibody-like construct where the C(H)1 and C(κ) domains are exchanged for a pair of the C(H)3 domains and efficient pairing of the heavy and light variable domain is achieved using “Knobs-into-Holes” strategy. This construct, composed of only naturally occurring immunogl...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891013/ https://www.ncbi.nlm.nih.gov/pubmed/29630643 http://dx.doi.org/10.1371/journal.pone.0195442 |