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Activation of TNF‐α/NF‐κB axis enhances CRL4B(DCAF) (11) E3 ligase activity and regulates cell cycle progression in human osteosarcoma cells
Cullin 4B, a member of the Cullins, which serve as scaffolds to facilitate the assembly of E3 ligase complexes, is aberrantly expressed in many cancers, including osteosarcoma. Recently, we observed that CUL4B forms the CRL4B(DCAF) (11) E3 ligase, which specifically ubiquitinates and degrades the cy...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891038/ https://www.ncbi.nlm.nih.gov/pubmed/29377600 http://dx.doi.org/10.1002/1878-0261.12176 |