Molecular dynamics simulations of site point mutations in the TPR domain of cyclophilin 40 identify conformational states with distinct dynamic and enzymatic properties

Cyclophilin 40 (Cyp40) is a member of the immunophilin family that acts as a peptidyl-prolyl-isomerase enzyme and binds to the heat shock protein 90 (Hsp90). Its structure comprises an N-terminal cyclophilin domain and a C-terminal tetratricopeptide (TPR) domain. Cyp40 is overexpressed in prostate c...

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Detalles Bibliográficos
Autores principales: Gur, Mert, Blackburn, Elizabeth A., Ning, Jia, Narayan, Vikram, Ball, Kathryn L., Walkinshaw, Malcolm D., Erman, Burak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIP Publishing LLC 2018
Materias:
ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891347/
https://www.ncbi.nlm.nih.gov/pubmed/29655319
http://dx.doi.org/10.1063/1.5019457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891347/
https://www.ncbi.nlm.nih.gov/pubmed/29655319
http://dx.doi.org/10.1063/1.5019457

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