Cargando…

Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element

There are currently no approved vaccines or small molecule therapeutics available for the prophylaxis or treatment of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infections. MERS-CoV 3CL protease is essential for viral replication; consequently, it is an attractive target that provides a...

Descripción completa

Detalles Bibliográficos
Autores principales: Galasiti Kankanamalage, Anushka C., Kim, Yunjeong, Damalanka, Vishnu C., Rathnayake, Athri D., Fehr, Anthony R., Mehzabeen, Nurjahan, Battaile, Kevin P., Lovell, Scott, Lushington, Gerald H., Perlman, Stanley, Chang, Kyeong-Ok, Groutas, William C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891363/
https://www.ncbi.nlm.nih.gov/pubmed/29544147
http://dx.doi.org/10.1016/j.ejmech.2018.03.004