Cargando…
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element
There are currently no approved vaccines or small molecule therapeutics available for the prophylaxis or treatment of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infections. MERS-CoV 3CL protease is essential for viral replication; consequently, it is an attractive target that provides a...
Autores principales: | Galasiti Kankanamalage, Anushka C., Kim, Yunjeong, Damalanka, Vishnu C., Rathnayake, Athri D., Fehr, Anthony R., Mehzabeen, Nurjahan, Battaile, Kevin P., Lovell, Scott, Lushington, Gerald H., Perlman, Stanley, Chang, Kyeong-Ok, Groutas, William C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Masson SAS.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891363/ https://www.ncbi.nlm.nih.gov/pubmed/29544147 http://dx.doi.org/10.1016/j.ejmech.2018.03.004 |
Ejemplares similares
-
Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies
por: Weerawarna, Pathum M., et al.
Publicado: (2016) -
Potent inhibition of enterovirus D68 and human rhinoviruses by dipeptidyl aldehydes and α-ketoamides
por: Kim, Yunjeong, et al.
Publicado: (2016) -
Protease inhibitors broadly effective against feline, ferret and mink coronaviruses
por: Perera, Krishani Dinali, et al.
Publicado: (2018) -
3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice
por: Rathnayake, Athri D., et al.
Publicado: (2020) -
Antiviral Drug Discovery: Norovirus Proteases and Development of Inhibitors
por: Chang, Kyeong-Ok, et al.
Publicado: (2019)