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Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element

There are currently no approved vaccines or small molecule therapeutics available for the prophylaxis or treatment of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infections. MERS-CoV 3CL protease is essential for viral replication; consequently, it is an attractive target that provides a...

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Detalles Bibliográficos
Autores principales:	Galasiti Kankanamalage, Anushka C., Kim, Yunjeong, Damalanka, Vishnu C., Rathnayake, Athri D., Fehr, Anthony R., Mehzabeen, Nurjahan, Battaile, Kevin P., Lovell, Scott, Lushington, Gerald H., Perlman, Stanley, Chang, Kyeong-Ok, Groutas, William C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Masson SAS. 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891363/ https://www.ncbi.nlm.nih.gov/pubmed/29544147 http://dx.doi.org/10.1016/j.ejmech.2018.03.004

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