Insufficiency of DNA repair enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection

T cells have a crucial role in viral clearance and vaccine response; however, the mechanisms regulating their responses to viral infections or vaccinations remain elusive. In this study, we investigated T-cell homeostasis, apoptosis, DNA damage, and repair machineries in a large cohort of subjects w...

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Detalles Bibliográficos
Autores principales: Zhao, Juan, Dang, Xindi, Zhang, Peixin, Nguyen, Lam Nhat, Cao, Dechao, Wang, Lin, Wu, Xiaoyuan, Morrison, Zheng D, Zhang, Ying, Jia, Zhansheng, Xie, Qian, Wang, Ling, Ning, Shunbin, EL Gazzar, Mohamed, Moorman, Jonathan P, Yao, Zhi Q
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891503/
https://www.ncbi.nlm.nih.gov/pubmed/29644094
http://dx.doi.org/10.1038/s41421-018-0015-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891503/
https://www.ncbi.nlm.nih.gov/pubmed/29644094
http://dx.doi.org/10.1038/s41421-018-0015-4

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