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Optimized Phenotypic Biomarker Discovery and Confounder Elimination via Covariate-Adjusted Projection to Latent Structures from Metabolic Spectroscopy Data
[Image: see text] Metabolism is altered by genetics, diet, disease status, environment, and many other factors. Modeling either one of these is often done without considering the effects of the other covariates. Attributing differences in metabolic profile to one of these factors needs to be done wh...
Autores principales: | Posma, Joram M., Garcia-Perez, Isabel, Ebbels, Timothy M. D., Lindon, John C., Stamler, Jeremiah, Elliott, Paul, Holmes, Elaine, Nicholson, Jeremy K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2018
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891819/ https://www.ncbi.nlm.nih.gov/pubmed/29457906 http://dx.doi.org/10.1021/acs.jproteome.7b00879 |
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