Cargando…

MDR1 overexpression combined with ERG11 mutations induce high-level fluconazole resistance in Candida tropicalis clinical isolates

BACKGROUND: Marked increases in fluconazole resistance in Candida tropicalis have been recently reported. In this study, the molecular mechanisms behind fluconazole resistance were investigated. METHODS: Twenty-two C. tropicalis clinical isolates, including 12 fluconazole-resistant isolates and 10 f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jin, Longyang, Cao, Zhuorui, Wang, Qi, Wang, Yichen, Wang, Xiaojuan, Chen, Hongbin, Wang, Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891969/ https://www.ncbi.nlm.nih.gov/pubmed/29631565 http://dx.doi.org/10.1186/s12879-018-3082-0

Ejemplares similares

Expression of ERG11, ERG3, MDR1 and CDR1 genes in Candida tropicalis
por: Rojas, Ana Elisa, et al.
Publicado: (2023)

Detection of ERG11 point mutations in Iranian fluconazole-resistant Candida albicans isolates
por: Sardari, Ali, et al.
Publicado: (2019)

Analysis of CDR1 and MDR1 Gene Expression and ERG11 Substitutions in Clinical Candida tropicalis Isolates from Alexandria, Egypt
por: El-Kholy, Mohammed A., et al.
Publicado: (2023)

P432 Detection of erg11 gene mutation in fluconazole resistant Candida albicans isolates
por: M.S., Sheena, et al.
Publicado: (2022)

The Role of ERG11 Point Mutations in the Resistance of Candida albicans to Fluconazole in the Presence of Lactate
por: Urbanek, Aneta K., et al.
Publicado: (2022)

Candida tropicalis distribution and drug resistance is correlated with ERG11 and UPC2 expression
por: Wang, Dan, et al.
Publicado: (2021)

Comparison of Human and Soil Candida tropicalis Isolates with Reduced Susceptibility to Fluconazole
por: Yang, Yun-Liang, et al.
Publicado: (2012)

Extensive ERG11 mutations associated with fluconazole-resistant Candida albicans isolated from HIV-infected patients
por: Paul, Sony, et al.
Publicado: (2019)

Rapid detection of ERG11 polymorphism associated azole resistance in Candida tropicalis
por: Paul, Saikat, et al.
Publicado: (2021)

Synergistic Antifungal Activity of Chitosan with Fluconazole against Candida albicans, Candida tropicalis, and Fluconazole-Resistant Strains
por: Lo, Wei-Hsuan, et al.
Publicado: (2020)

Fluconazole-Resistant Candida parapsilosis Bloodstream Isolates with Y132F Mutation in ERG11 Gene, South Korea
por: Choi, Yong Jun, et al.
Publicado: (2018)

Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing
por: Wang, Huiping, et al.
Publicado: (2009)

A New Variant of Mutational and Polymorphic Signatures in the ERG11 Gene of Fluconazole-Resistant Candida albicans
por: Odiba, Arome Solomon, et al.
Publicado: (2022)

ERG11 Gene Mutations and MDR1 Upregulation Confer Pan-Azole Resistance in Candida tropicalis Causing Disseminated Candidiasis in an Acute Lymphoblastic Leukemia Patient on Posaconazole Prophylaxis
por: You, Liangshun, et al.
Publicado: (2017)

Clonality of Fluconazole-Nonsusceptible Candida tropicalis in Bloodstream Infections, Taiwan, 2011–2017
por: Chen, Pao-Yu, et al.
Publicado: (2019)

Antiproliferation of Berberine in Combination with Fluconazole from the Perspectives of Reactive Oxygen Species, Ergosterol and Drug Efflux in a Fluconazole-Resistant Candida tropicalis Isolate
por: Shao, Jing, et al.
Publicado: (2016)

Investigation of fluconazole susceptibility to Candida albicans by MALDI-TOF MS and real-time PCR for CDR1, CDR2, MDR1 and ERG11
por: Maenchantrarath, Chanika, et al.
Publicado: (2022)

Synergistic Effect of Pseudolaric Acid B with Fluconazole Against Resistant Isolates and Biofilm of Candida tropicalis
por: Li, Zhen, et al.
Publicado: (2020)

Overexpression of MDR-1 and CDR-2 genes in fluconazole resistance of Candida albicans isolated from patients with vulvovaginal candidiasis
por: Khosravi Rad, K, et al.
Publicado: (2016)

Computational insights into fluconazole resistance by the suspected mutations in lanosterol 14α-demethylase (Erg11p) of Candida albicans
por: Prakash, Sagunthala Murugesan Udaya, et al.
Publicado: (2020)

Quantitation of ergosterol content and gene expression profile of ERG11 gene in fluconazole-resistant Candida albicans
por: Alizadeh, F, et al.
Publicado: (2017)

High prevalence of fluconazole resistant Candida tropicalis among candiduria samples in China: An ignored matter of concern
por: Fan, Xin, et al.
Publicado: (2023)

Effect of biogenic selenium nanoparticles on ERG11 and CDR1 gene expression in both fluconazole-resistant and -susceptible Candida albicans isolates
por: Parsameher, Nasrin, et al.
Publicado: (2017)

Regulation of ERG3, ERG6, and ERG11 Genes in Antifungal-Resistant isolates of Candida parapsilosis
por: Lotfali, Ensieh, et al.
Publicado: (2017)

Multilocus Sequence Typing Reveals Clonality of Fluconazole-Nonsusceptible Candida tropicalis: A Study From Wuhan to the Global
por: Wang, Qianyu, et al.
Publicado: (2020)

Recent Increase in the Prevalence of Fluconazole-Non-susceptible Candida tropicalis Blood Isolates in Turkey: Clinical Implication of Azole-Non-susceptible and Fluconazole Tolerant Phenotypes and Genotyping
por: Arastehfar, Amir, et al.
Publicado: (2020)

Multilocus sequence analyses reveal extensive diversity and multiple origins of fluconazole resistance in Candida tropicalis from tropical China
por: Wu, Jin-Yan, et al.
Publicado: (2017)

Overexpression of Both ERG11 and ABC2 Genes Might Be Responsible for Itraconazole Resistance in Clinical Isolates of Candida krusei
por: He, Xiaoyuan, et al.
Publicado: (2015)

Farnesol Boosts the Antifungal Effect of Fluconazole and Modulates Resistance in Candida auris through Regulation of the CDR1 and ERG11 Genes
por: Dekkerová, Jaroslava, et al.
Publicado: (2022)

Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species
por: Silva, Danielly Beraldo dos Santos, et al.
Publicado: (2016)

Mechanisms of Azole Resistance and Trailing in Candida tropicalis Bloodstream Isolates
por: Chen, Pao-Yu, et al.
Publicado: (2021)

Whole Genome Sequencing Shows Genetic Diversity, as Well as Clonal Complex and Gene Polymorphisms Associated with Fluconazole Non-Susceptible Isolates of Candida tropicalis
por: Keighley, Caitlin, et al.
Publicado: (2022)

Limited ERG11 Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility
por: Healey, Kelley R., et al.
Publicado: (2018)

First detection of mutated ERG11 gene in vulvovaginal Candida albicans isolates at Ouagadougou/Burkina Faso
por: Dovo, Essi Etonam, et al.
Publicado: (2022)

Molecular epidemiology of Candida tropicalis isolated from urogenital tract infections
por: Wang, Qianyu, et al.
Publicado: (2020)

The A756T Mutation of the ERG11 Gene Associated With Resistance to Itraconazole in Candida Krusei Isolated From Mycotic Mastitis of Cows
por: Du, Jun, et al.
Publicado: (2021)

Lack of Association between Fluconazole Susceptibility and ERG11 Nucleotide Polymorphisms in Cryptococcus neoformans Clinical Isolates from Uganda
por: Atim, Priscilla Belbir, et al.
Publicado: (2022)

Novel Polymorphic Multilocus Microsatellite Markers to Distinguish Candida tropicalis Isolates
por: Fan, Xin, et al.
Publicado: (2016)

Inhibitors of the Candida albicans Major Facilitator Superfamily Transporter Mdr1p Responsible for Fluconazole Resistance
por: Keniya, Mikhail V., et al.
Publicado: (2015)

Fructose Induces Fluconazole Resistance in Candida albicans through Activation of Mdr1 and Cdr1 Transporters
por: Suchodolski, Jakub, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_l0ad9i70jludgtsso8qh6a9fd5