Iatrogenic metrorrhagia after the use of itraconazole for onychomycosis

We present first case report on itraconazole, a drug very commonly used for onychomycosis, used along with simvastatin that caused metrorrhagia. The suggested probable mechanism is the inhibition of steroidogenesis, especially estrogens that resulted in low-estrogen breakthrough bleeding. This artic...

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Autores principales: Brzezinski, Piotr, Gulin, Sandra Jerkovic, Gulin, Dario, Chiriac, Anca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Drug Watch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892030/
https://www.ncbi.nlm.nih.gov/pubmed/29674803
http://dx.doi.org/10.4103/ijp.IJP_838_16
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author Brzezinski, Piotr
Gulin, Sandra Jerkovic
Gulin, Dario
Chiriac, Anca
author_facet Brzezinski, Piotr
Gulin, Sandra Jerkovic
Gulin, Dario
Chiriac, Anca
author_sort Brzezinski, Piotr
collection PubMed
description We present first case report on itraconazole, a drug very commonly used for onychomycosis, used along with simvastatin that caused metrorrhagia. The suggested probable mechanism is the inhibition of steroidogenesis, especially estrogens that resulted in low-estrogen breakthrough bleeding. This article emphasizes the importance of drug interaction check prior the initiation of onychomycosis treatment.
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spelling pubmed-58920302018-04-19 Iatrogenic metrorrhagia after the use of itraconazole for onychomycosis Brzezinski, Piotr Gulin, Sandra Jerkovic Gulin, Dario Chiriac, Anca Indian J Pharmacol Drug Watch We present first case report on itraconazole, a drug very commonly used for onychomycosis, used along with simvastatin that caused metrorrhagia. The suggested probable mechanism is the inhibition of steroidogenesis, especially estrogens that resulted in low-estrogen breakthrough bleeding. This article emphasizes the importance of drug interaction check prior the initiation of onychomycosis treatment. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5892030/ /pubmed/29674803 http://dx.doi.org/10.4103/ijp.IJP_838_16 Text en Copyright: © 2018 Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Drug Watch
Brzezinski, Piotr
Gulin, Sandra Jerkovic
Gulin, Dario
Chiriac, Anca
Iatrogenic metrorrhagia after the use of itraconazole for onychomycosis
title Iatrogenic metrorrhagia after the use of itraconazole for onychomycosis
title_full Iatrogenic metrorrhagia after the use of itraconazole for onychomycosis
title_fullStr Iatrogenic metrorrhagia after the use of itraconazole for onychomycosis
title_full_unstemmed Iatrogenic metrorrhagia after the use of itraconazole for onychomycosis
title_short Iatrogenic metrorrhagia after the use of itraconazole for onychomycosis
title_sort iatrogenic metrorrhagia after the use of itraconazole for onychomycosis
topic Drug Watch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892030/
https://www.ncbi.nlm.nih.gov/pubmed/29674803
http://dx.doi.org/10.4103/ijp.IJP_838_16
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