Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer’s disease mouse models

Alzheimer’s disease (AD) is characterized by neurotoxicity mediated by the accumulation of beta amyloid (Aβ) oligomers, causing neuronal loss and progressive cognitive decline. Genetic deletion or chronic pharmacological inhibition of mGluR5 by the negative allosteric modulator CTEP, rescues cogniti...

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Detalles Bibliográficos
Autores principales: Abd-Elrahman, Khaled S., Hamilton, Alison, Vasefi, Maryam, Ferguson, Stephen S. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892040/
https://www.ncbi.nlm.nih.gov/pubmed/29631635
http://dx.doi.org/10.1186/s13041-018-0364-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892040/
https://www.ncbi.nlm.nih.gov/pubmed/29631635
http://dx.doi.org/10.1186/s13041-018-0364-9

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